The analogues are reversed (left-handed control), and you can not switch to left-handed ... ...

Maybe, it can be. Lucky you. But I'm used to switch to left-hand controls in other games. I also play the guitar and I'm not able to play regular, as a right-handed. Sea Of Thieves don't have a option to change for left-handed player.

Ive set up Forza and Flight simulator for my partner who can only use the left hand

I set up the up/down/left/right on the PDP one handed controller to forward/reverse/left/right

Honestly, do the tutorials. Everyone is so unique in their abilities that you can learn what you need, particuarly from MSFS just by playing those

For that you need throttle up/down, landing gear, flaps, rudder, and the general stick as bare minimums with all assists on

I have a left handed hammer and some left handed screwdrivers if you need some

You must hold LEFT or the RIGHT on the D-PAD. NOT the analog sticks. you hold the right d-pad down and you will see a number show up next to the item highlighted to hotkey that item to the right d pad.

Also, quick tip, you can actually switch between three things with two handed items.

.

lets say you have a two handed item hot keyed to the d pad(lets use right), and you have two spells in your hand, you hit the right d-pad, you switch to your two handed weapon, when you hit right on the d pad again, its brings up the two spells you last
had in your hand. same with the left. you can have a two handed weapon on the left, and a bow on the right, and duel wield two weapons or spells and switch between all three of them on the fly.

.

This is how you can switch between three things.

.

I have poisons hotkeyed to the left d-pad and my bow hotkeyed to the left, and when I need to heal, I hit the right on my d-pad to unequip my bow and that brings up my conjur spell and healing spell and then I hit the right d-pad again to switch back to
my bow and then I hit the left d pad to use a poison on the bow.

Should be in the player creation part