Combo Meal Please (GUI Group B)

It will definetly depend on what the mission entails. If you're up against Blue Suns/Geth a good combo could be Zaeed (disruptor ammolvl 3 or H.disruptor ammo) and whichever character you want i.e biotic approach Jack/Miranda/Samara, guns heavy Grunt/Garrus
etc... Eclipse/Blood Pack/Collectors Miranda (Heavy Warp) and again whichever character you want to approach as and aid.

Infiltrators are pretty much covered to handle anything with disruptive ammo/incineration powers plus you got cryo ammo and hacking. If you top that with either reave/dominate you have a juggernaut in your hands.

One thing I love to approach is creating a hybrid of Infiltrator/Hunter by selecting the shotgun at the Collector's Ship. Combine that with enhanced cloak and geth shotgun and you can pretty much obliterate anything up close and personal or afar with no
problem.

PD the viper rifle is highly effective, I have come to prefer it even over the widow. And imo the cryo ammo is very very underrated.

hope that helps!

if you are going to play infiltrator class, stick with Miranda, she will help you deal with the foe's barriers and shield protection (which you cannot deal yourself). The remain squad member depends on which mission or assignment you are going to do.

For example, Garrus is for the fight with enemies have shield protection, Thane for dealing with barriers but he is not as good as Miranda for destroying the shields, Tali or Legion is for dealing with the mechs or using combat drone etc.

After playing the game and started on my second playthrough, during the upgrade stages of game a though ran through my mind.

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So, different missions require different things to accomplish and since I had so much element zero left, would it be best to figure out what each mission entails, choose the option to re-allocate your points thus leading to a different sort of character
with each mission. Would that be better overall or make more sense?

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(First time I shot everything in sight, now I found out just how much fun it is to combine different effects during battle, so reasoning for my question above.)

Group combo question of sorts. Since you have quite a bit of element zero, would it be better if I reset Sheppard's character, then choose to create one specific for a mission for each corresponding mission or simply stay with preferred character?

For me it depends on difficulty, if you're doing it on insane Garrus' overload and and Mordin's incineration are perfect for that play-trough in my opinion, if it's normal i'd use Grunt just send him at the enemy with fortification on.